Expression of a novel peptide derived from PCNA damages DNA and reverses cisplatin resistance
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چکیده
منابع مشابه
The Identification of a Novel Peptide Derived from Lactoferrin Isolated from Camel Milk with Potential Antimicrobial Activity
Background and Objective: Antimicrobial peptides have attracted significant attention in recent decades because of their properties, such as rapid bactericidal effects, having a wide spectrum of activity, and a rare development of drug resistance. The purpose of this study was to examine the antibacterial activity of a peptide derived from the lactoferrin isolated from camel milk against Staphy...
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Cisplatin is a potent cytotoxic agent that functions as a bivalent electrophile, forming both interstrand and intrastrand DNA cross-links. Cisplatin-mediated DNA damage results in cell cycle arrest and initiation of apoptotic cell death. Increased cellular glutathione concentrations have been closely correlated with cisplatin resistance but do not reduce the extent of cisplatin-DNA adduct forma...
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ژورنال
عنوان ژورنال: Cancer Chemotherapy and Pharmacology
سال: 2014
ISSN: 0344-5704,1432-0843
DOI: 10.1007/s00280-014-2574-x